Most definitely yes.
I have found that many colleges love home schoolers because they are more independent learners and fit better into the college model of learning. That said you need to make sure they have the right course load for their potential major and college. Pick a few likely colleges (like University of Delaware, for example) and see what their general entrance requirements are.
If you even think that your children may be interested in some type of science or music career check out the science and music departments and see what (if any) additional requirements they have. Then start mapping out your children’s four years of high school.
I would definitely leave room in their senior year for any courses you haven’t planned on but might find out later that they need. It is easier to not get overwhelmed if you start this process early.